Throughout the season, new storylines were introduced, including the love-triangle between Meredith Grey, Derek Shepherd, and Addison Montgomery, this being the main arc of the season. Whereas the first season put the emphasis mainly on the unexpected impact the surgical field has on the main characters, the second season provides a detailed perspective on the personal background of each character, focusing on the consequences that their decisions have on their careers. It was set in the fictional Seattle Grace Hospital, located in the city of Seattle, Washington. The season continued to focus on the surgical residency of five young interns as they try to balance the challenges of their competitive careers with the difficulties that determine their personal lives. Previous main cast members Chandra Wilson, James Pickens, Jr., Isaiah Washington and Patrick Dempsey also returned, while Kate Walsh, who began the season in a recurring capacity, was promoted to series-regular status, after appearing in 7 episodes as a guest-star. Knight reprised their roles as surgical interns Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O'Malley respectively. Actors Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, and T. The season was produced by Touchstone Television, in association with Shondaland production company and The Mark Gordon Company, the showrunner being Shonda Rhimes. The second season of the American television medical drama Grey's Anatomy commenced airing on the American Broadcasting Company (ABC) on September 25, 2005, and concluded on May 15, 2006.

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